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Researcher at Universidad de Santiago developed a new immunotherapy for cancer

Researcher at Universidad de Santiago developed a new immunotherapy for cancer

  • The new therapy involves the development of a vaccine that provides the immune system with the tools needed to “attack” cancer cells, improving the antitumour response of the body. The therapy was announced to foreign media correspondents accredited in Chile.

  • The study is funded through a Fondecyt Project and it is at preclinical stage. It considers a significant decrease of more than 70% in the overall cost of therapies for this disease.
  • The leader of the project, Claudio Acuña, Dr in Biomedical Sciences, researcher, and Head of the Department of Biology of our University, gave us some details on this new technology, which is applying for a patent in USA with the support of Corfo.
  • Dr Acuña said: “We are generating a quite effective therapy for cancer through which we could make immunotherapy more available to people. We are doing this in a university which is known for its social responsibility signature. In this context, I would like to highlight the talent of my students involved in this project.”

 

In order to optimize cancer therapy and contribute to public health in our country, an innovative and significant treatment developed at Universidad de Santiago has recently been presented.

This project involves the development of a vaccine that will allow destroying cancer cells in the body by enhancing its immune response.

This scientific development- funded by the National Fund for Scientific and Technological Development, Fondecyt- considers a significant decrease of more than 70% in the overall costs of cancer therapies and it has shown an efficacy of 50%.

Dr Claudio Acuña, Head of the Department of Biology of Universidad de Santiago, is leading the project. “We want to have a vaccine available to protect us from the disease, just like in the vaccination process for measles and other diseases when we are children. In the case of cancer, our idea is to get people vaccinated so that they are able to eliminate cancer cell in their bodies, he said.”

Quality of life

According to the researcher, the project “Seeks to improve the quality of life of patients in the long term and generate a supplementary therapy to conventional treatments to resist cancer in a non-conventional way, which is currently treated with chemotherapy.”

“We have completed the preclinical stage (trials in living animals) which showed that the vaccine does protect from the disease. The next step is the clinical phase, in which it will be tested in human subjects. There was not any negative effect on animals, so we could extrapolate that there will be not any effect on patients,” he added.

“The ultimate goal is to generate a vaccine for people with cancer that will allow enhancing their immune response to tumours,” he said.

We are generating a quite effective therapy for cancer in which we could make immunotherapy more available to people. We are doing this in a university which is known for its social responsibility signature. In this context, I would like to highlight the talent of my students involved in this project,” the scientist said.

 

“We were able to make it because the University enables, favours and promotes these innovation processes, besides providing the confidence to conduct high-level research,” he added.

 

Dicyt project

Dr Acuña’s meeting with foreign media correspondents was in the context of the activities of a Dicyt Public Opinion Project of Universidad de Santiago, led by Gabriela Martínez Cuevas, professor at the Department of Journalism.

 

Professor Martínez highlighted the interest of Fundación Imagen de Chile in contributing to promote the significance of this study among a group of accredited correspondents in Chile.

“Due to the strategic partnership that we developed with Fundación Imagen de Chile last year in a similar project, we have been able to arrange the first of a series of conferences with foreign accredited correspondents, during 2015,” professor Martínez said.

“This body has the purpose of managing the “nation branding”, so we have joined efforts to strengthen our “U de Santiago brand” around the world through our scientists,” she added.

Gabriela Martínez, who is also Director of the Communications Department and the institutional radio station said: “Today, the interest of the international press for learning about this study led by Dr Claudio Acuña was evident, and he insisted on the importance of the contribution made by the young researchers that he is training.”

She said: “There were correspondents of all the agencies in Europe, China and Latin America. We expect to see how they inform the world about this new contribution made by our state and public University, which is committed to the country progress and gives solutions to urgent demands beyond our borders. This was specifically demonstrated with this cancer vaccine.”

The project- which is at its preclinical stage- is based on effects of Polymixin B. It has already shown its first results in lymphoma, melanoma and breast, with an effectiveness of almost 50%. Besides, it is worth to mention that this technology could decrease the cost of current traditional cancer therapies by up to 70%.

With the support of the Chilean Economic Development Agency (Corfo, in Spanish), this technology is in the patenting process both in Chile and USA, to then continue to the clinical stage and to exporting the treatment.

Fundación Imagen de Chile

According to its web page, Fundación Imagen de Chile is an autonomous institution funded by public resources, created in 2009, with the purpose of coordinating and organizing the efforts to promote the image of Chile abroad.

Its responsibility is to mange the “nation branding”, by coordinating the work of the main sectors that contribute to build this image, such as culture, sports, exportations, investments, tourism and international relations, among others. For this purpose, the foundation develops strategic partnerships with public and private agents to coordinate the image of the country and actively position the distinctive features of our identity.

Translated by Marcela Contreras

Researchers analyzed relationship between fish stress and losses in salmon farming industry

Researchers analyzed relationship between fish stress and losses in salmon farming industry

  • The study suggests that stress in fish may be causing economic losses for the country due to its impact on the production of salmon farming industry.

According to the Chilean Undersecretariat for Fishing and Aquaculture’s report of October 2015, exports last August reached 93 different countries, likes USA, Japan, Brazil, Rusia, China and others.

The importance of this strategic productive sector to Chile's economy, led Dr Claudio Acuña Castillo, Head of the Department of Biology and researcher at the Aquaculture Biotechnology Center (CBA, in Spanish) and his colleagues at Universidad de Santiago and other institutions, to conduct a literature review to understand the stress-generating mechanisms in fish, in comparison to mammals. 

The analysis entitled Neuroendocrine mechanisms for immune system regulation during stress in fish was published on the Fish and Shellfish Immunology journal. The article has had a high impact on the scientific community and has been cited in other scientific works, allowing to go deeper in an insufficiently studied subject. “It has contributed to understand some aspects of stress in fish and to help other researchers who are interested in the same subject,” Dr Acuña said.

According to the researcher, major causes of stress among farmed fish are overcrowding, relocation, vaccines and transitions between freshwater and saltwater. The latter process happens normally in nature, but in productive contexts, it causes stress and affects the immune system of fish.

Chronic stress and acute stress

When analyzing stress in fish, Dr Acuña emphasizes that we must consider that fish are not mammals, therefore, they have a different behavior. They have different regulation mechanisms, different anatomy and a lonely life, as they are not gregarious animals.

All living organisms need some stress to develop. “Chronic stress is dangerous and harmful. When it becomes permanent, it affects the immune system. However, acute stress is necessary and useful, as it contributes to decision-making in conflict situations,” he explained.

When stress becomes chronic, it can be perceived in different ways. “Fish show physiological and behavioral changes, aggressiveness, and, sometimes, loss of appetite and increased susceptibility to contagious diseases,” he said.

Impact on aquaculture production

According to Dr Acuña, “It is highly probable that stress in fish may be having an impact on the production losses of salmon farming industry. When stress is too much, fish become susceptible to sea lice, for example. So, when all the produced fish die, as it is happening now, maybe there are not only genetic causes but stress-related factors.”

The researcher is also very worried about the side effects of production losses: lack of jobs and unemployment. He thinks that, if we begin to understand the process, we will be able to provide solutions. 

Besides, Dr Acuña expects to reduce the stress effects in fish by using natural solutions, like plants or natural elements.

The article was also led by Dr Ricardo Fernández, researcher at the Faculty of Biological Sciences and the Faculty of Medicine of Universidad Andrés Bello. Dr Gino Nardocci, Dr Cristina Navarro and Dr Paula P. Cortes, of Universidad Andrés Bello, and Dr Mónica Imarai, Dr Margarita Montoya, Dr Beatriz Valenzuela and Dr Pablo Jara, researchers at the Faculty of Chemistry and Biology and the CBA of Universidad de Santiago, collaborated with the study.

Translated by Marcela Contreras

Researchers at Universidad de Santiago develop innovative LED communication device for underground mining operations

Researchers at Universidad de Santiago develop innovative LED communication device for underground mining operations

  • The system will allow sending text, audio and video messages over long distances and at high speeds in underground mining operations. The project is led by Dr Ismael Soto, director of the Getic Laboratory of the Department of Electrical Engineering, and Dr Carolina Lagos Aguirre, alternate director of the project.

 

 

The system consists of a new device about the size of a cell phone that will enable good communications in underground mining operations by sending text, audio and video messages over long distances and at high speeds. 

Tech-Lifim (communication technology through visible light in mining operations) is a LED light-based device that transmits and decodes data through light pulses. The project is one of the research works conducted by the Department of Electrical Engineering of Universidad de Santiago de Chile.

The study is being developed by the Getic Laboratory of Universidad de Santiago (which is focused on digital signal processing for wireless communications), led by Dr Ismael Soto and Dr Carolina Lagos Aguirre, with the participation of graduate and undergraduate students at the university.

Exploring new needs

The project was started in 2010, when links were established with the Chuquicamata Division (the largest open pit copper producer in the world) of de Chilean’s National Corporation of Copper (Codelco, in Spanish), with the purpose of conducting studies on copper mining. “We gathered information about their needs and one of the issues they mentioned was the lack of communication devices, particularly for underground mining operations,” Dr Lagos says. “They asked us to develop a device able to transmit data at high speed and under adverse conditions, like high temperature, high humidity, dust and smoke.”

The research team established a strategic partnership with the company Control & Logic and started to work on the device. For a year and a half, they have continued with the research work, performed some tests and given presentations in Chuquicamata. “The device can be placed on the workers’ helmets, on underground tunnels’ walls and on trucks, to guarantee a simultaneous communication,” she says.

Global impact

According to the researchers, the system, which is currently at the production stage, is very efficient and meets the workers’ safety requirements.

Universidad de Santiago de Chile has already filed a patent request in Chile for this product. The next step will be filing a request abroad, because of a global underground mining project led by Codelco that will be started in 2019, based on the systems being implemented in Chuquicamata now,” Dr Soto explains.

In this context, they have created a company supported by the Innovo Usach business incubator. “We have the goal of placing the product in the market and start its commercialization in January 2017. Although we have worked with Chuquicamata for now, the device will be available for everyone who needs it,” the researcher says.

Other studies

This communication device is an example of the many studies that this research team intends to conduct. “We are also developing a lighting system for underground mining operations that will be available in the years to come,” Dr Soto says.

Besides, the research team is working on other projects in collaboration with foreign institutions like Northumbria University (England), the Oil and Gas University of Ploiesti (Romania) and the University of Lorraine (France).

Translated by Marcela Contreras

Food protective film is developed using local byproducts

Food protective film is developed using local byproducts

  • Universidad de Santiago’s interdisciplinary research team, led by Dr. Silvia Matiacevich from the Technological Faculty, is focused on developing an edible film that could increase the shelf life of fresh foods by 30%.

Improving the way of preserving foods has been a permanent concern in food industry. This is the reason why packaging is essential for the quality and shelf life of the product. But this packaging should be in harmony with the environment.

In light of this situation, a sustainable alternative for food packaging has been developed: food covering edible films, which are being widely used and have become a world trend nowadays. At Universidad de Santiago, an interdisciplinary research team is trying to replicate this development, giving value added to different national byproducts.

This initiative will be viable thanks to the Associative Dicyt Project called “Bioactive Coatings for Foods”, which gathers together experts from different faculties of the University.

“We will use food industry byproducts which are considered as dispensable or waste material. We are going to give them a value added by adding antioxidant and antimicrobial components to them in order to increase the shelf life of fresh food products,” Dr. Daniel López says.

Academics from three different faculties gathered for this purpose: Dr. Rubén Bustos, from the Faculty of Engineering (Department of Chemical Engineering); Dr. Diego Venegas and Dr. Marlén Gutiérrez, from the Faculty of Chemistry and Biology (Department of Materials Chemistry); and Dr. Daniel López and Dr. Silvia Matiacevich, from the Technological Faculty (Department of Food Science and Technology), being Dr. Matiacevich the leader of the project.

During the two years scheduled for the project, the researchers plan to study the synergistic effect of this combination of products and they expect to increase food shelf life by over 30%.

Interdisciplinarity

Most of the academics related to this project are part of a larger group created by the end of 2013 called Indi, Asociación de Investigadores por el Desarrollo e Interdisciplinariedad of Universidad de Santiago de Chile, a group of researchers that promotes development and interdisciplinarity at the university.

“All of us have participated in some of these initiatives at some point, seeking for this interdisciplinarity. This is how we have met other people and created contacts. What is good is that more than just admiring the work of others, we have the real possibility of conducting studies together. For this reason, we value this type of projects, as they promote the integration and interdisciplinarity that define a university,” Dr. Matiacevich says.

Translated by Marcela Contreras
 

Researchers study nanoparticles to prolong the effect of cancer-fighting drugs

Researchers study nanoparticles to prolong the effect of cancer-fighting drugs

  • In order to develop more tolerable therapies, a research team at the Faculty of Chemistry and Biology of Universidad de Santiago de Chile studies the use of biodegradable nanoparticles to increase the Adenosine Triphosphate (ATP) circulation time in the body to combat cancer.

 

In order to develop more tolerable therapies, a research team at the Faculty of Chemistry and Biology of Universidad de Santiago de Chile studies the use of biodegradable nanoparticles to increase the Adenosine Triphosphate (ATP) circulation time in the body to combat cancer.

The study is led by Dr Patricia Díaz, professor at the Faculty of Chemistry and Biology and is being developed in the context of the 2016 Fondecyt Post Doc Project (3160837) "Uso de nanopartículas con circulación prolongada para la administración de ATP en tratamientos anticancerígenos." Dr Díaz and her team will test new nanotechnology-based applications to deliver cancer-fighting drugs into the body.

She explains that any drug delivered in the body for therapeutic purposes requires a circulation time to play its therapeutic role.

Some molecules, like ATP, are quickly degraded, so high constant drug doses are required to be therapeutically effective and this is not beneficial for patients.

“As drugs are encapsulated in nanoparticles, the enzymes that metabolize them cannot bind to them. This is why they are protected against degradation. Consequently, drugs’ half-life is increased, prolonging its therapeutic efficacy,” she explains. 

Improved treatments

The advantage of using ATP as a cancer-fighting drug is that it has minor side effects if compared to other drugs. But ATP degrades very quickly when it is recognized by the enzymes in the body. Therefore, different drug administration methods are required, like the use of nanoparticles with biodegradable and biocompatible properties.

“For this reason, we want to encapsulate ATP into biocompatible nanoparticles to increase its half-life. We will also use other strategies to make them invisible to the immune system, so that they can circulate longer. The idea is to prevent them from binding to the cell and to avoid extracellular release of ATP. In this way, we expect to have a higher amount of drug available in the body for a prolonged anti-cancer effect,” she explains.

According to Dr Díaz, the main objective of the study is to test the effectiveness of ATP-carrying nanoparticles in cancer treatment. “I expect to demonstrate that nanoparticle-encapsulated drugs increase their bioavailability when compared with conventional administration methods. Besides, we also expect to analyze the potential synergistic effect of administrating ATP in combination with other drugs frequently used in cancer treatment.”

“This synergistic effect could destroy a higher number of cancer cells, benefiting patients with advanced cancer,” she adds.

Another advantage of this type of treatment is that, as it allows a sustained release of drugs in time, patients could receive the treatment once a week or every two or more weeks, depending on the drug encapsulation capacity and its circulation time,” she concludes. 

Dr Juan Pablo García-Huidobro, researcher at the Faculty of Chemistry and Biology, is also participating in the study, which is being conducted at the Pharmacology Laboratory.

 

Translated by Marcela Contreras



 

Universidad de Santiago opens new research building

Universidad de Santiago opens new research building

  • With a space of 2,755 m2, the five-floored building will be home to the Center for the Development of Nanoscience and Nanotechnology, the Aquaculture Biotechnology Center and the Soft Matter Center. The cost of the building construction amounted to about CLP 5,000 million.

 

 

In a context in which Chile only invests 0.39 of its GDP in research, the President of Universidad de Santiago de Chile, Dr Juan Manuel Zolezzi, highlighted the importance of this new space that will contribute to research and development in the country.

“This is one of the state-of-the arts buildings in Chile with regard to university research and it is an incentive for new researchers to continue innovating in key areas for the development of Chile,” he said. He added that Universidad de Santiago de Chile is a leader in technology transfer.

Senator Guido Girardi, who heads the Challenges for the Future. Science, Technology and Innovation Commission of the Upper House, valued the work done by public universities.

“These universities take charge of basic sciences on their own. Particularly, Universidad de Santiago has had the wisdom to connect basic sciences to the problems of the country and to generate innovation to solve these problems,” he said.

A few months ago, Dr Girardi visited the Center for the Development of Nanoscience and Nanotechnology (Cedenna, in Spanish) where he met with professionals in this significant research field. After the opening ceremony he congratulated the university on the new facilities.

The centers

Representatives of the centers that will occupy the new facilities expressed their satisfaction with the architectural configuration of the building that facilitates research development.

Dr Francisco Melo, Head of the Soft Matter Center that gathers together scientists in the fields of Physics, Chemistry, Biology and Engineering, said that the new space will offer endless opportunities for a better science development and for positioning the university at an international level.

For her part, Dr Dora Altbir, Head of the Cedenna, said that the possibility of bringing together scientists from different fields will allow a more active collaboration than the one that the university has now.

Eugenio Spencer Ossa, Head of the Aquaculture Biotechnology Center (CBA, in Spanish) said that the new building will allow to further scientific research and contribute to improve domestic industrial production, like salmon farming.

Architecture

The Rector Eduardo Morales Santos Research Building, with a total surface of 2,755.15 m2, is located in the central campus of the university. Its design is a geometric reinterpretation of the heritage buildings of the institution designed by the architects Héctor Valdés, Fernando Castillo Velasco, Carlos García Huidobro and Carlos Bresciani and built between 1957 and 1967. The building’s name is a tribute to the first democratically-elected university president after the dictatorship.

 

Translated by Marcela Contreras

New compound to prolong shelf life of dairy products

New compound to prolong shelf life of dairy products

  • The project led by Dr Silvia Matiacevich, professor at the Department of Food Science and Technology of the Technological Faculty, seeks to renew food industry by developing a compound with antimicrobial and antioxidant properties to prolong shelf life of dairy products. The project is funded through a Fondecyt Regular project 2016.

 

 

Nowadays, fresh, healthy and natural food consumption has increased, particularly, the intake of dairy products. According to the Chilean Bureau for Agricultural Studies and Policies (ODEPA; in Spanish), in 2013 the intake per capita was 146.5 liter, a national record in the country. 

However, these products require additives for their preservation that are not always natural and that do not allow a balanced and healthy diet.

In this context, Dr Silvia Matiacevich, professor at the Department of Food Science and Technology of the Technological Faculty; Dr Rubén Bustos, professor at the Department of Chemical Engineering of the Faculty of Engineering, and students at both units formed an interdisciplinary research team that will work on the study “Prolonged release of natural active compounds for improving shelf life of a dairy food matrix: Effect of structure obtained by different encapsulation process”. The project is funded by a Fondecyt Regular project (1160463) and it seeks to find a new active compound to preserve dairy products by means of nanotechnology. 

“We want to develop a new active ingredient with antimicrobial and antioxidant properties for dairy foods, in such a way that the compound has a prolonged release during storage, extending the product’s shelf life,” Dr Matiacevich says.

With this in mind, the researchers intend to study how the structure generated in this active ingredient- a powder developed through two different techniques- modifies its prolonged release in time in a real matrix,” she adds.

Food innovation and collaborative work

The objective of the study is to evaluate the effect of the structure obtained through “different encapsulation processes in prolonged release during storage of an encapsulated active agent,” in order to prolong the shelf life of a milk-based food matrix.

“By using encapsulation processes it is possible to obtain nanometric-sized particles, so the principles of nanotechnology are involved in this development,” favoring the compound prolonged release,” Dr Rubén Bustos, co-researcher of this study, says.

Food innovation research has increased worldwide. In Latin America, there are several research groups. For example, there are centers in Argentina, Colombia and Brazil, which professionals will collaborate in this project.

According to Dr Matiacevich, the main contribution of this study lies in that they will work directly with foods, so the study will not only provide basic knowledge but it will be applied to a real matrix.

For his part, Dr Bustos stresses the importance of their work with nanotechnology by saying: “At some point, microencapsulated ingredients were the greatest breakthrough, but now we will work with nanoencapsulated compounds, with much smaller and innovative structures.”

For the research team, the most important fact in relation to this project is that it involves the collaborative work of two departments of two different faculties of Universidad de Santiago de Chile. They also value the support of the Vice Presidency of Research, Development and Innovation, and the collaborative work with national and foreign universities. 

 

Translated by Marcela Contreras

Researchers at Universidad de Santiago develop hydrogen-based technology

Researchers at Universidad de Santiago develop hydrogen-based technology

  • Dr Daniel Serafini and Dr Álvaro San Martín, both professors at the Department of Physics, have developed an innovative solution that allows to store energy as hydrogen. One of the advantages of this technology is that it is not intermittent as current non-conventional energy sources (NCES), like solar and wind energy. This project is a contribution of Universidad de Santiago de Chile to the energy industry.

 

An innovative technology to store energy as hydrogen is being developed by Dr Daniel Serafini and Dr Álvaro San Martín, both professors at the Department of Physics of Universidad de Santiago de Chile.

According to Dr Serafini, one of the advantages of this technology is that it is not intermittent as current non-conventional energy sources (NCES), like solar and wind energy.

Hydrogen is generated during off-peak periods via water electrolysis. Then, depending on the needs, electric power is generated using the hydrogen stored in an electrochemical device called fuel cell. This system is very efficient and is environmentally friendly, because hydrogen combustion only generates water vapour, free of greenhouse gases and particulate matter.

Storing energy as hydrogen is a better solution in comparison to lithium batteries. “We compete with lithium batteries and they are much more expensive and heavier and they have technological problems regarding their size, i.e., at equal size, they have a more reduced capacity,” Dr Serafini says.

According to the expert, with current battery technology, lithium reserves in the world “are enough to cover only 40% of the cars in the Unites States.”

It is also worth to mention that this solution is particularly attractive to settlements in remote areas that do not receive power supply from the interconnected grid system.

The researchers implemented a demonstration module at the Minera San Pedro mining camp, in Til Til (at the north of the Metropolitan Region), where the pilot project has been working since mid-2015.

The CLP150 million project has been funded by the Innova Chile program of the Chilean Economic Development Agency (CLP132 million) and Minera San Pedro.

Greater involvement of the private sector

For his part, Dr San Martín stresses that the project has been well received by the Government and that now, a greater involvement of the private sector is required. “In developed countries, different public and private programs to develop hydrogen technologies have been funded with millions of dollars for a long time,” he says.

State-run bodies in Chile have already recognized the importance of hydrogen in the future for a clean non-polluting public transport. Both researchers agree that this is an essential starting point. 

Target market

One of the benefits of implementing this type of technology in Chile is that we have enormous ENCS resources of all kinds (solar, wind, geothermal, hydroelectric and tidal power), but they are intermittent, so the use of hydrogen would be highly convenient. 

The researchers say that this project “is not targeted at large companies for now, but remote places, like small settlements or fishing villages away from interconnected grid systems, little mine sites and road construction zones, etc.”

They expect to fully implement the project by mid-2016. Although they acknowledge that it is necessary to make this technology more price competitive, they say that costs have significantly fallen in recent times due to the huge development of fuel cell vehicles.

 

Translated by Marcela Contreras

Scientist works on mathematical model to prevent wooden structures from collapsing

Scientist works on mathematical model to prevent wooden structures from collapsing

  • Dr Erick Saavedra Flores, researcher at the Department of Civil Works Engineering of Universidad de Santiago de Chile, is studying new mathematical techniques to computer simulate the performance of wood at extreme ranges of deformation, cracking and ductile processes and its possible progressive collapse.

 

Wooden structures in a seismic country like Chile require constant inspection to check on its resistance in case of critical events such as earthquakes.

Dr Erick Saavedra Flores, researcher at the Department of Civil Works Engineering of Universidad de Santiago de Chile, is studying new mathematical techniques to computer simulate the performance of wood at extreme ranges of deformation, cracking and ductile processes and, eventually, in a progressive collapse.

Dr Saavedra explains that failures in wooden structures are divided into two groups: brittle and ductile failures. Both will determine the time before wood collapses. “Usually, structures fail abruptly, without previous notice. This type of failure is classified as ‘brittle’. However, at a local level, close to metal joints or fittings, wood fails in a “ductile” manner, i.e., it fails gradually in time. This latter type of failure is very common in very high buildings made of wood,” he says.

With the resources provided by a Fondecyt Regular project, Dr Saavedra will present a new model based on a mathematical technique called “homogenization”, which seeks to detect cracking and irreversible deformation processes at different spatial scales.

Worldwide efforts

“Achieving this goal will be a big challenge, because we require to extend the existing theory to incorporate the damage factor, i.e., degradation, loss of material stiffness and cracks into the multi-scale mechanical response of the material. In the past few years, big efforts have been made worldwide; however, predicting the mechanical performance of materials in this context remains to be a problem without a solution that is fully accepted by the scientific community,” he says.

He explains that he intends to incorporate this new material model to the advanced analysis of large-scale structures, because the big challenge posed by this goal is to computer simulate the progressive collapse of structures during seismic events.

In this regard, modeling this problem is extremely difficult as it involves extreme deformation processes, the interaction of elements that fall during the collapse process and their consequent fragmentation.

The project also considers experimental testing to validate the numerical predictions obtained during the study. Running these tests will be possible with the acquisition of a vibrating table for the Department of Civil Works Engineering.

As a final result of this study, the researcher expects to have material advanced models able to capture extreme deformation processes that allow to calculate ductility measures.

“I believe that the major impact my project may have is in the area of design and construction of buildings and large-scale structures. In the case of wood, particularly, it is possible to promote the use of radiata pine to construct tall buildings if we have a more precise knowledge of its performance during failures or eventual structural collapse,” Dr Saavedra explains. 

The study will be conducted in the context of the Fondecyt Regular project 2016 (1160691), “Advanced Modelling of Ductility and Damage in Mass Timber Structures by Computational Homogenization.”

 

Translated by Marcela Contreras

Study on lizards’ movements in granular environments could contribute to robotics

Study on lizards’ movements in granular environments could contribute to robotics

  • With the funding of a Fondecyt Postdoctoral Project 2016, Dr Baptiste Darbois, professor at the Faculty of Science of Universidad de Santiago, will be able to accurately determine how lizards move in granular soils in order to produce results that allow to create a robot able to move easily in different types of soil.

 

With the funding of a Fondecyt Postdoctoral Project 2016, Dr Baptiste Darbois, professor at the Faculty of Science of Universidad de Santiago, will be able to accurately determine how lizards move in granular soils in order to produce results that allow to create a robot able to move easily in different types of soil. This would mean a significant contribution to robotics.

Based on previous research that found that once lizards dive in the sand, they move by wriggling their bodies and not by using their legs, Dr Darbois will study the interaction between a vibrating elastic structure and the granular environment.

The Fondecyt Postdoctoral project (3160167) is called “Locomoción ondulatoria de nadadores suaves dentro de los medios granulares.”

Experimental challenge

The experimental challenge of the study is to control the movement of grains and the forces they undergo when lizards move. This would help to establish guidelines for developing robots able to adapt themselves to different environments. The way of moving of different animals has inspired engineers in this field.

“We expect the compression produced by lizards’ undulating movements in the desert’s sub-surface to help us to develop efficient robots by incorporating this mechanism,” Dr Darbois explained.

Likewise, professor Darbois intends to develop, in the long term, a robot based on the best features lizards show when moving in a granular environment.

“Through this project, we expect to define the optimal conditions: the dimensions, elasticity, frequency and amplitude of vibrations to move forward in waves through a granular environment,” the researcher said.

The relationship between lizards and the development of robots is not odd; on the contrary, it can benefit technological development and improve people´s quality of life. For example, it can be used in critical situations.

“With regard to its applications, developing robots able to efficiently move in granular environments could help to detect anti-personnel mines in the deserts and find people trapped under avalanches,” Dr Darbois concluded.

Translated by Marcela Contreras

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